Of mice and not men: differences between mouse and human immunology.

Mouse and Human Immunology Of Mice and Not Men: Differences between

Route of Infection Affects Pathogenicity of Leishmania major in BALB/c Mice

Introduction: The term Leishmaniasis applies to a group of parasitic diseases caused by the genus Leishmania. Route of infection is one of the variables that have been reported to influence the immune responses as well as the disease outcome in experimental models of leishmaniasis. This research aims to study the effect of route of infection on the pathogenicity of Leishmania major in BALB/c mi...

Evaluating Muscle Activity During Work With Trackball, Trackpad, Slanted, and Standard Mice

Objectives: Mouse is one of the most important data entry devices for computers. Undesirable and prolonged postures during work with the computer mouse increase workload, muscle aches and upper extremity musculoskeletal disorders. The present study aimed to evaluate and compare muscle activity during the use of 4 types of mouse, including trackball, trackpad, slanted and standard by Electromyog...

Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies

Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered fr...

P-230: Analysis of TEX15 Expression in Testis Tissues of Severe Oligozoospermic and Non-Obstructive Azoospermic Men Referred to Royan Institute

Background: TEX15 is a novel protein that is required for chromosomal synapsis and meiotic recombination. Human TEX15 is located on chromosome 8(8p12 region) and expressed in testis and ovary, as is its mouse ortholog. Loss of TEX15 function in mice causes early meiotic arrest in males but not in females. Specifically, TEX15 deficient spermatocytes exhibit a failure in chromosomal synapsis. In ...

Western Blot Analysis of Sera from Leishmania major-Infected BALB/c and C57BL/6 Mice

In Leishmania (L.) major-infected BALB/c mice Th2-type cells results in disease progression, whereas C57BL/6-infected mice mount a Th1-type response, which leads to control of the infection. Th2 response correlates with IgG1 whereas, Th1 response supports switching to IgG2a subclasses. Since IgG isotype-dominated response depends on different CD4 + T cell subsets, we studied the antigenic profi...